This is my sentiment as well. I think mechanistically we have confidence the vaccines work as they generate antibodies and immune memory that wouldn't have to be sterilizing. It's just that this Duke 'cohort' is not a good one to look at for a signal since it's so young. Same in trying to study efficacy among children... there's just nothing work with since the disease does nothing to them anyway, even at vast scales much less small study sizes.
Vaccines probably do work, but uptake in the low risk age groups likely won't make much of a difference in deaths or even hospitalizations. With the knowledge that natural immunity is stronger, it's a strong argument against mandates and for continued investment in treatments while still advocating to vaccinate the vulnerable.
This is my sentiment as well. I think mechanistically we have confidence the vaccines work as they generate antibodies and immune memory that wouldn't have to be sterilizing. It's just that this Duke 'cohort' is not a good one to look at for a signal since it's so young. Same in trying to study efficacy among children... there's just nothing work with since the disease does nothing to them anyway, even at vast scales much less small study sizes.
Vaccines probably do work, but uptake in the low risk age groups likely won't make much of a difference in deaths or even hospitalizations. With the knowledge that natural immunity is stronger, it's a strong argument against mandates and for continued investment in treatments while still advocating to vaccinate the vulnerable.